冷冻切片（FS）是手术操作期间组织微观评估的制备方法。该程序的高速允许病理学医师快速评估关键的微观特征，例如肿瘤边距和恶性地位，以引导手术决策，并尽量减少对操作过程的干扰。然而，FS容易引入许多误导性的人工结构（组织学人工制品），例如核冰晶，压缩和切割人工制品，妨碍了病理学家的及时和准确的诊断判断。额外的培训和长期经验通常需要对冻结部分进行高度有效和时间关键的诊断。另一方面，福尔马林固定和石蜡嵌入（FFPE）的黄金标准组织制备技术提供了显着优越的图像质量，而是一种非常耗时的过程（12-48小时），使其不适合术语用。在本文中，我们提出了一种人工智能（AI）方法，通过在几分钟内将冻结的整个幻灯片（FS-WSIS）计算冻结的整个幻灯片（FS-WSIS）来改善FS图像质量。 AI-FFPE将FS人工制品终止了注意力机制的指导，该引导机制在利用FS输入图像和合成的FFPE样式图像之间利用建立的自正则化机制，以及综合相关特征的合成的FFPE样式图像。结果，AI-FFPE方法成功地生成了FFPE样式图像，而不会显着扩展组织处理时间，从而提高诊断准确性。我们证明了使用各种不同的定性和定量度量，包括来自20个董事会认证的病理学家的视觉图灵测试的各种不同的定性和定量度量。

With the proliferation of deep generative models, deepfakes are improving in quality and quantity everyday. However, there are subtle authenticity signals in pristine videos, not replicated by SOTA GANs. We contrast the movement in deepfakes and authentic videos by motion magnification towards building a generalized deepfake source detector. The sub-muscular motion in faces has different interpretations per different generative models which is reflected in their generative residue. Our approach exploits the difference between real motion and the amplified GAN fingerprints, by combining deep and traditional motion magnification, to detect whether a video is fake and its source generator if so. Evaluating our approach on two multi-source datasets, we obtain 97.17% and 94.03% for video source detection. We compare against the prior deepfake source detector and other complex architectures. We also analyze the importance of magnification amount, phase extraction window, backbone network architecture, sample counts, and sample lengths. Finally, we report our results for different skin tones to assess the bias.

Though impressive success has been witnessed in computer vision, deep learning still suffers from the domain shift challenge when the target domain for testing and the source domain for training do not share an identical distribution. To address this, domain generalization approaches intend to extract domain invariant features that can lead to a more robust model. Hence, increasing the source domain diversity is a key component of domain generalization. Style augmentation takes advantage of instance-specific feature statistics containing informative style characteristics to synthetic novel domains. However, all previous works ignored the correlation between different feature channels or only limited the style augmentation through linear interpolation. In this work, we propose a novel augmentation method, called \textit{Correlated Style Uncertainty (CSU)}, to go beyond the linear interpolation of style statistic space while preserving the essential correlation information. We validate our method's effectiveness by extensive experiments on multiple cross-domain classification tasks, including widely used PACS, Office-Home, Camelyon17 datasets and the Duke-Market1501 instance retrieval task and obtained significant margin improvements over the state-of-the-art methods. The source code is available for public use.

One of the main challenges in electroencephalogram (EEG) based brain-computer interface (BCI) systems is learning the subject/session invariant features to classify cognitive activities within an end-to-end discriminative setting. We propose a novel end-to-end machine learning pipeline, EEG-NeXt, which facilitates transfer learning by: i) aligning the EEG trials from different subjects in the Euclidean-space, ii) tailoring the techniques of deep learning for the scalograms of EEG signals to capture better frequency localization for low-frequency, longer-duration events, and iii) utilizing pretrained ConvNeXt (a modernized ResNet architecture which supersedes state-of-the-art (SOTA) image classification models) as the backbone network via adaptive finetuning. On publicly available datasets (Physionet Sleep Cassette and BNCI2014001) we benchmark our method against SOTA via cross-subject validation and demonstrate improved accuracy in cognitive activity classification along with better generalizability across cohorts.

Development of guidance, navigation and control frameworks/algorithms for swarms attracted significant attention in recent years. That being said, algorithms for planning swarm allocations/trajectories for engaging with enemy swarms is largely an understudied problem. Although small-scale scenarios can be addressed with tools from differential game theory, existing approaches fail to scale for large-scale multi-agent pursuit evasion (PE) scenarios. In this work, we propose a reinforcement learning (RL) based framework to decompose to large-scale swarm engagement problems into a number of independent multi-agent pursuit-evasion games. We simulate a variety of multi-agent PE scenarios, where finite time capture is guaranteed under certain conditions. The calculated PE statistics are provided as a reward signal to the high level allocation layer, which uses an RL algorithm to allocate controlled swarm units to eliminate enemy swarm units with maximum efficiency. We verify our approach in large-scale swarm-to-swarm engagement simulations.

The development of deep learning based image representation learning (IRL) methods has attracted great attention in the context of remote sensing (RS) image understanding. Most of these methods require the availability of a high quantity and quality of annotated training images, which can be time-consuming and costly to gather. To reduce labeling costs, publicly available thematic maps, automatic labeling procedures or crowdsourced data can be used. However, such approaches increase the risk of including label noise in training data. It may result in overfitting on noisy labels when discriminative reasoning is employed as in most of the existing methods. This leads to sub-optimal learning procedures, and thus inaccurate characterization of RS images. In this paper, as a first time in RS, we introduce a generative reasoning integrated label noise robust representation learning (GRID) approach. GRID aims to model the complementary characteristics of discriminative and generative reasoning for IRL under noisy labels. To this end, we first integrate generative reasoning into discriminative reasoning through a variational autoencoder. This allows our approach to automatically detect training samples with noisy labels. Then, through our label noise robust hybrid representation learning strategy, GRID adjusts the whole learning procedure for IRL of these samples through generative reasoning and that of the other samples through discriminative reasoning. Our approach learns discriminative image representations while preventing interference of noisy labels during training independently from the IRL method. Thus, unlike the existing methods, GRID does not depend on the type of annotation, label noise, neural network, loss or learning task, and thus can be utilized for various RS image understanding problems. Experimental results show the effectiveness of GRID compared to state-of-the-art methods.

The use of deep neural networks (DNNs) has recently attracted great attention in the framework of the multi-label classification (MLC) of remote sensing (RS) images. To optimize the large number of parameters of DNNs a high number of reliable training images annotated with multi-labels is often required. However, the collection of a large training set is time-consuming, complex and costly. To minimize annotation efforts for data-demanding DNNs, in this paper we present several query functions for active learning (AL) in the context of DNNs for the MLC of RS images. Unlike the AL query functions defined for single-label classification or semantic segmentation problems, each query function presented in this paper is based on the evaluation of two criteria: i) multi-label uncertainty; and ii) multi-label diversity. The multi-label uncertainty criterion is associated to the confidence of the DNNs in correctly assigning multi-labels to each image. To assess the multi-label uncertainty, we present and adapt to the MLC problems three strategies: i) learning multi-label loss ordering; ii) measuring temporal discrepancy of multi-label prediction; and iii) measuring magnitude of approximated gradient embedding. The multi-label diversity criterion aims at selecting a set of uncertain images that are as diverse as possible to reduce the redundancy among them. To assess this criterion we exploit a clustering based strategy. We combine each of the above-mentioned uncertainty strategy with the clustering based diversity strategy, resulting in three different query functions. Experimental results obtained on two benchmark archives show that our query functions result in the selection of a highly informative set of samples at each iteration of the AL process in the context of MLC.

In computer-aided drug discovery (CADD), virtual screening (VS) is used for identifying the drug candidates that are most likely to bind to a molecular target in a large library of compounds. Most VS methods to date have focused on using canonical compound representations (e.g., SMILES strings, Morgan fingerprints) or generating alternative fingerprints of the compounds by training progressively more complex variational autoencoders (VAEs) and graph neural networks (GNNs). Although VAEs and GNNs led to significant improvements in VS performance, these methods suffer from reduced performance when scaling to large virtual compound datasets. The performance of these methods has shown only incremental improvements in the past few years. To address this problem, we developed a novel method using multiparameter persistence (MP) homology that produces topological fingerprints of the compounds as multidimensional vectors. Our primary contribution is framing the VS process as a new topology-based graph ranking problem by partitioning a compound into chemical substructures informed by the periodic properties of its atoms and extracting their persistent homology features at multiple resolution levels. We show that the margin loss fine-tuning of pretrained Triplet networks attains highly competitive results in differentiating between compounds in the embedding space and ranking their likelihood of becoming effective drug candidates. We further establish theoretical guarantees for the stability properties of our proposed MP signatures, and demonstrate that our models, enhanced by the MP signatures, outperform state-of-the-art methods on benchmark datasets by a wide and highly statistically significant margin (e.g., 93% gain for Cleves-Jain and 54% gain for DUD-E Diverse dataset).

全球地球观察（EO）的运营能力不断增长为数据驱动的方法创造了新的机会，以理解和保护我们的星球。但是，由于巨大的档案尺寸和EO平台提供的有限的勘探功能，目前使用EO档案的使用受到了极大的限制。为了解决这一限制，我们最近提出了米兰，这是一种基于内容的图像检索方法，用于在卫星图像档案中快速相似性搜索。米兰是基于公制学习的深层哈希网络，将高维图像特征编码为紧凑的二进制哈希码。我们将这些代码用作哈希表中的钥匙，以实现实时邻居搜索和高度准确的检索。在此演示中，我们通过将米兰与Agoraeo内的浏览器和搜索引擎集成在一起来展示米兰的效率。地震支持卫星图像存储库上的交互式视觉探索和典型查询。演示访问者将与地震互动，扮演不同用户的角色，这些用户的角色通过其语义内容搜索图像，并通过其语义内容搜索并应用其他过滤器。

本文考虑了多个Antenna基站和用户设备对上行链路性能的一般硬件障碍的影响。首先，当使用有限大小的信号星座时，有效通道是分析得出的失真感知接收器。接下来，设计和训练了深层喂食神经网络，以估计有效的渠道。将其性能与最先进的失真感和不知道的贝叶斯线性最小均时误差（LMMSE）估计器进行了比较。提出的深度学习方法通过利用损伤特性来提高估计质量，而LMMSE方法将失真视为噪声。